Targeting glycosaminoglycans to treat enlarged prostate and related fibrosis
Official title: Glycosaminoglycan Targeting Treatment for Prostatic Hyperplasia and Fibrosis
Funded at Augusta University · NIH-10943239 · Data updated 2026-11-12
This study is looking at how a substance called hyaluronic acid affects the symptoms of benign prostatic hyperplasia (BPH) in older men, and it will test a safe oral medication that could help reduce these symptoms by lowering hyaluronic acid levels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | August 21, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $629,250 |
| NIH project number | 1R01DK140376-01 |
| Project ID | NIH-10943239 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are aging men experiencing lower urinary tract symptoms related to benign prostatic hyperplasia.
✕Less likely to help
Patients with prostate conditions unrelated to benign prostatic hyperplasia or those who do not experience lower urinary tract symptoms may not benefit from this research.
What this research studies
This research focuses on benign prostatic hyperplasia (BPH), a common condition in aging men that leads to lower urinary tract symptoms (LUTS). The study aims to understand the role of hyaluronic acid, a type of glycosaminoglycan, in the progression of BPH and its associated symptoms. Researchers will evaluate the clinical significance of elevated hyaluronic acid levels in prostate tissues and test an oral medication that inhibits its synthesis, which has shown a good safety profile. By using mouse models, the research will explore the relationship between inflammation, fibrosis, and BPH symptoms.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatment options for men suffering from benign prostatic hyperplasia.
How similar studies have gone: Previous research has indicated that targeting glycosaminoglycans may be a promising approach in treating conditions associated with inflammation and fibrosis, suggesting potential for success in this area.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Lokeshwar, Vinata B — Augusta University
- Study coordinator: Lokeshwar, Vinata B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.