Targeting Glioblastoma's Treatment Resistance with Artificial MicroRNAs
Harnessing Artificial MicroRNA Clusters Against Glioblastoma Epigenetic Plasticity and Resistance to Therapy
This project explores how tiny genetic tools called microRNAs can make glioblastoma brain tumors more sensitive to current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10761730 on NIH RePORTER |
What this research studies
Glioblastoma is a very serious brain cancer in adults that often resists standard treatments like chemotherapy and radiation. This resistance happens because tumor cells activate special defense mechanisms, controlled by specific proteins. Our team has found that certain natural microRNAs can block these proteins, making tumor cells more vulnerable to stress. This project aims to understand exactly how these defense mechanisms work and then create a gene therapy using artificial microRNAs. The goal is to weaken the tumor's protective shield, making existing therapies more effective for patients.
Who could benefit from this research
Good fit: This research focuses on understanding and developing new strategies for treating glioblastoma in adult patients.
Not a fit: Patients without glioblastoma or those not receiving standard therapies may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this approach could make current glioblastoma treatments work better, potentially improving patient outcomes and extending survival.
How similar studies have performed: Preliminary work in lab and animal models has shown promise for this approach, demonstrating that re-expressing these microRNAs can sensitize tumor cells to stress.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Peruzzi, Pier Paolo — Brigham and Women's Hospital
- Study coordinator: Peruzzi, Pier Paolo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.