Targeting FTO to improve radiation therapy for certain cancers
Project 4: FTO Inhibition to Enhance the Therapeutic Index of Radiotherapy
This study is looking at whether blocking a certain enzyme can make radiation therapy work better for people with cervical and lung cancers, with the hope of shrinking tumors and helping patients live longer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10914189 on NIH RePORTER |
What this research studies
This research investigates the potential of inhibiting a specific enzyme called FTO to enhance the effectiveness of radiation therapy for solid tumors, particularly cervical and non-small cell lung cancers. By targeting cancer-specific metabolic pathways, the study aims to improve tumor response to radiation, potentially reducing tumor growth and increasing patient survival rates. The approach involves both genetic and pharmacological methods to assess the impact of FTO inhibition on tumor cells in laboratory settings. If successful, this could lead to more effective treatment options for patients undergoing radiation therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older diagnosed with cervical cancer or non-small cell lung cancer.
Not a fit: Patients with cancers not targeted by this research or those under 21 years old may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for patients receiving radiation therapy for certain types of cancer.
How similar studies have performed: Preliminary studies have shown promising results in targeting FTO for cancer treatment, indicating potential for success in this approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Rankin, Erinn B — Stanford University
- Study coordinator: Rankin, Erinn B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.