Targeting fatty acid metabolism to treat colon cancer
Fatty Acid Synthase as a Novel Molecular Target for Colon Cancer Treatment
This study is looking at how fat processing in the body affects colon cancer and is testing new medications that target a specific enzyme to help improve treatment for people with colorectal cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11039999 on NIH RePORTER |
What this research studies
This research investigates the role of fatty acid metabolism in colon cancer and how it contributes to tumor growth and treatment resistance. The study focuses on a key enzyme, fatty acid synthase (FASN), which is crucial for cancer cell survival and proliferation. Researchers are developing and testing new small molecule inhibitors that specifically target FASN, aiming to improve treatment outcomes for patients with colorectal cancer. The approach includes clinical trials to evaluate the safety and effectiveness of these inhibitors in patients with resectable colon cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with resectable colon cancer who are seeking new treatment options.
Not a fit: Patients with advanced or metastatic colon cancer who are not eligible for surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for colon cancer, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in targeting fatty acid metabolism in cancer treatment, indicating potential for success with this novel approach.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Gao, Tianyan — University of Kentucky
- Study coordinator: Gao, Tianyan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.