Targeting epigenetic mechanisms in a type of acute leukemia
Official title: Combinational Targeting the Feed-forward Epigenetic Circuitry in Mixed Lineage Leukemia
Funded at Beckman Research Institute/city of Hope · NIH-11023022 · Data updated 2026-11-12
This study is looking at how certain biological processes affect mixed lineage leukemia (MLL-r) and aims to find better treatment options by exploring new combination therapies that target specific enzymes involved in the disease.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $362,340 |
| NIH project number | 5R37CA233691-07 |
| Project ID | NIH-11023022 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with MLL-rearranged acute leukemia who have limited treatment options.
✕Less likely to help
Patients with other types of leukemia or those who do not have MLL-rearranged leukemia may not benefit from this research.
What this research studies
This research investigates the role of specific epigenetic mechanisms in mixed lineage leukemia (MLL-r), a type of acute leukemia with poor prognosis. The study focuses on the interaction between the DOT1L enzyme and the PHF20/KAT8 histone acetyltransferase complex, which are crucial for maintaining the expression of oncogenes in this cancer. By exploring combination therapies that target these mechanisms, the research aims to develop more effective treatment options for patients. The methodology includes advanced techniques such as CRISPR for discovering functional elements involved in leukemia progression.
Why it matters
Potential benefit: If successful, this research could lead to more effective targeted therapies for patients with MLL-rearranged leukemias.
How similar studies have gone: Other research has shown promising results with targeted therapies in similar contexts, indicating potential for success in this novel approach.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Chen, Chun-Wei David — Beckman Research Institute/city of Hope
- Study coordinator: Chen, Chun-Wei David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.