Targeting DNA repair in lung cancer with KRAS mutations using chemical screening
Targeting DNA repair in KRAS mutated lung cancer by chemical screening
This study is looking for new treatments for lung cancer patients with KRAS mutations, aiming to find natural compounds that can help make their cancer more responsive to chemotherapy, so they have better options for fighting their disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10650366 on NIH RePORTER |
What this research studies
This research focuses on developing new treatments for lung cancer patients with KRAS mutations, which are often resistant to standard therapies. By screening a library of natural compounds, the study aims to identify small molecules that can inhibit DNA repair mechanisms in cancer cells, making them more susceptible to chemotherapy. The approach involves testing various compounds to find those that effectively enhance the effectiveness of existing cancer treatments. Patients may benefit from new therapeutic options that specifically target their cancer's unique genetic profile.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with KRAS mutated non-small cell lung cancer (NSCLC).
Not a fit: Patients with lung cancer that does not have KRAS mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with KRAS mutated lung cancer.
How similar studies have performed: Previous research has shown promise in using chemical screening to identify effective treatments for various cancers, indicating potential success for this approach.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Zhang, You-Wei — Case Western Reserve University
- Study coordinator: Zhang, You-Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.