Targeting DNA changes to treat Huntington's disease
Official title: Therapeutic targeting of DNA methyltransferases in Huntington's disease
Funded at Washington University · NIH-11042817 · Data updated 2026-11-12
This study is looking at how changing certain chemical tags on DNA might help slow down Huntington's disease by using mice to see how these changes affect the brain and behavior, with the hope of finding new ways to treat people with the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $194,375 |
| NIH project number | 5R21NS133823-02 |
| Project ID | NIH-11042817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Huntington's disease, particularly those in the early stages of the condition.
✕Less likely to help
Patients with advanced Huntington's disease or those without a confirmed diagnosis may not benefit from this research.
What this research studies
This research investigates how altering DNA methylation can affect gene expression and potentially slow down the progression of Huntington's disease (HD). By using mouse models, the study aims to understand how these changes impact brain function and behavior in HD. The researchers will administer a DNA demethylating agent and observe its effects on the disease's pathology and symptoms. This approach seeks to uncover new therapeutic targets that could lead to effective treatments for patients suffering from HD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of Huntington's disease and improve the quality of life for patients.
How similar studies have gone: While targeting DNA methylation is a relatively novel approach in Huntington's disease, similar strategies have shown promise in other neurodegenerative conditions, suggesting potential for success.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Yano, Hiroko — Washington University
- Study coordinator: Yano, Hiroko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.