Targeting CMG2 to treat pain from endometriosis
CMG2 as a target for safe and effective treatment of endometriosis-associate pain
This study is looking at a special protein called CMG2 to see if it can help reduce pain for women with endometriosis, aiming to find better treatment options than what’s currently available.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10583339 on NIH RePORTER |
What this research studies
This research investigates the role of CMG2, a receptor involved in tissue growth and pain, as a potential target for treating pain associated with endometriosis. Endometriosis affects many women and is often inadequately managed with current treatments like NSAIDs and hormonal therapies. The study aims to understand how targeting CMG2 can reduce pain and improve treatment outcomes by exploring its biological mechanisms and safety in preclinical models. If successful, this approach could lead to new, effective therapies for women suffering from endometriosis-related pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of childbearing age who experience chronic pelvic pain due to endometriosis.
Not a fit: Patients who do not have endometriosis or those whose pain is not related to this condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for women suffering from endometriosis-associated pain.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for pain management, but this specific approach with CMG2 is novel.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Rogers, Michael Sean — Boston Children's Hospital
- Study coordinator: Rogers, Michael Sean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.