Targeting CD38 to improve imaging of multiple myeloma
Official title: CD38-TARGETED IMMUNOPET OF MYELOMA: PHASE 2 TRIAL OF CLINICAL APPLICATIONS
Funded at Hoag Memorial Hospital Presbyterian · NIH-10918289 · Data updated 2026-11-12
This study is testing a new imaging technique to help people with multiple myeloma see how much of the cancer is in their body, which could lead to better treatment choices and monitoring.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hoag Memorial Hospital Presbyterian NIH-funded |
| Lab location | 1 site (Newport Beach, United States) |
| Project start | July 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $560,238 |
| NIH project number | 5R01CA248398-04 |
| Project ID | NIH-10918289 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple myeloma who are undergoing treatment or monitoring.
✕Less likely to help
Patients with other types of blood cancers or those not diagnosed with multiple myeloma may not benefit from this research.
What this research studies
This research focuses on enhancing the imaging of multiple myeloma, a type of blood cancer, using a specialized technique called CD38-targeted immunoPET. By utilizing a radiolabeled monoclonal antibody, the study aims to visualize the disease burden in patients more effectively than current methods. The trial will assess how well this imaging correlates with standard laboratory tests and imaging techniques, potentially leading to better treatment decisions and monitoring. Patients with multiple myeloma may benefit from this innovative approach that seeks to provide a clearer picture of their disease.
Why it matters
Potential benefit: If successful, this research could lead to more accurate assessments of multiple myeloma, improving treatment strategies and patient outcomes.
How similar studies have gone: Previous studies using targeted imaging techniques have shown promise in improving disease visualization, suggesting a potential for success in this novel approach.
Where this research is happening
-
Hoag Memorial Hospital Presbyterian
Newport Beach, United States Active
Researchers
- Principal investigator: Ulaner, Gary Allan — Hoag Memorial Hospital Presbyterian
- Study coordinator: Ulaner, Gary Allan
Related research
Other NIH-funded projects on the same topics.
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Integrative study of multiple myeloma genetics and disease biology
A team at Dana-Farber and partners is pursuing a long-term project to understand the genetic and molecular drivers of multiple myeloma and how treatments interact with disease biology.
-
Comparative Modeling to Prevent, Detect Early, and Treat Multiple Myeloma
A research team will build and compare computer models to understand how multiple myeloma develops, can be detected earlier, and treated more effectively.
-
How LDL Affects Multiple Myeloma: New Pathways to Keep Remission
A new grant is studying how cholesterol from LDL particles fuels multiple myeloma and how this interaction influences the tumor environment and immune response, with goals to help patients stay in remission.
-
Therapy-induced senescence and immune activation in multiple myeloma
A study in people with multiple myeloma will explore how treatment-related senescence in cancer cells may stimulate the immune system and affect cancer return after standard frontline therapy.
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BCMA CAR-T enteritis: understanding immune toxicities in multiple myeloma
A broad study to uncover why some CAR-T cell treatments targeting BCMA cause severe intestinal inflammation in people with multiple myeloma.
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Understanding Drug-Resistant Multiple Myeloma to Stop Relapse
Researchers are studying why some myeloma cells resist treatment and how to create new therapies to prevent relapse.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.