Targeting cancer stem cells in glioblastoma
Official title: Targeting Glioblastoma Stem Cells
Funded at University of Pittsburgh at Pittsburgh · NIH-10982682 · Data updated 2026-11-12
This study is looking at how glioblastoma, a tough type of brain cancer, grows and resists treatment, especially as people age, to find better ways to fight it by understanding the special cells that help the tumor survive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2031 |
| Funding year | 2024 |
| Award (this year) | $954,000 |
| NIH project number | 1R35CA283998-01A1 |
| Project ID | NIH-10982682 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with glioblastoma, particularly those who are older and may have a more complex tumor biology.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research investigates the complex nature of glioblastoma, a highly aggressive brain cancer, by focusing on the role of cancer stem cells and how aging affects tumor development and treatment resistance. The study aims to understand the cellular and molecular mechanisms that allow these tumors to thrive despite treatment efforts. By exploring the unique environment of neural stem cells and their interactions within glioblastoma, the research seeks to develop more effective therapeutic strategies that can overcome the challenges posed by these resilient cancer cells.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, improving survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown promise in targeting cancer stem cells in other types of cancers, suggesting that this approach may also be effective for glioblastoma.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Rich, Jeremy N — University of Pittsburgh at Pittsburgh
- Study coordinator: Rich, Jeremy N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.