Targeting cancer stem cells in colorectal cancer
Targeting colorectal cancer stem cells with ALDH1B1 antagonists
This study is looking at new ways to treat colorectal cancer by targeting special cells that help tumors grow, focusing on a protein called ALDH1B1, to hopefully improve outcomes for patients, especially those with more advanced cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11088843 on NIH RePORTER |
What this research studies
This research focuses on colorectal cancer, a leading cause of cancer-related deaths worldwide. It aims to develop new treatments by targeting cancer stem cells, which are believed to contribute to tumor growth and relapse. The researchers are investigating a specific protein, ALDH1B1, that is crucial for the survival of these cancer stem cells. By creating selective antagonists for ALDH1B1, the study seeks to improve treatment outcomes for patients with colorectal cancer, particularly those with advanced stages of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer, especially those with advanced or metastatic disease.
Not a fit: Patients with early-stage colorectal cancer who are responding well to standard treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies that significantly improve survival rates for colorectal cancer patients.
How similar studies have performed: Previous research has shown promise in targeting cancer stem cells, but this specific approach using ALDH1B1 antagonists is novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Chen, James K — Stanford University
- Study coordinator: Chen, James K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.