Targeting cancer stem cells in a specific type of nerve tumor
Targeting the Cancer Stem Cells in Malignant Peripheral Nerve Sheath Tumor
['FUNDING_R37'] · MEDICAL COLLEGE OF WISCONSIN · NIH-10894937
This study is looking at a type of nerve-related cancer called malignant peripheral nerve sheath tumors (MPNST) to better understand how certain cancer cells help the tumors grow and spread, with the hope of finding new ways to treat it.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-10894937 on ClinicalTrials.gov |
What this research studies
This research investigates malignant peripheral nerve sheath tumors (MPNST), a type of cancer associated with nerves. It focuses on understanding the role of cancer stem cells (CSCs) in these tumors and how they contribute to tumor growth and metastasis. By studying the interactions between these CSCs and their nerve microenvironment, the research aims to identify potential therapeutic targets. The approach includes using mouse models and examining specific signaling pathways that may drive tumor initiation and progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with malignant peripheral nerve sheath tumors.
Not a fit: Patients with other types of tumors or cancers unrelated to malignant peripheral nerve sheath tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target cancer stem cells in MPNST, potentially improving patient outcomes.
How similar studies have performed: Other research has shown promise in targeting cancer stem cells in various cancers, suggesting that this approach may be effective for MPNST as well.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, DAOCHUN — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: SUN, DAOCHUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer Cell Differentiation Factor P45, Cancers