Targeting cancer cells with specific enzyme inhibitors
Pro-Drug Enolase Inhibitors in Precision Oncology
This study is exploring a new way to treat certain cancers by targeting a weakness in the cancer cells, hoping to create a treatment that can kill those cells without harming healthy ones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11010746 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treating certain cancers by exploiting genetic vulnerabilities. It focuses on cancers that have lost a key tumor suppressor gene, leading to reliance on a related enzyme for survival. By developing a specific inhibitor for this enzyme, the research aims to selectively kill cancer cells while sparing normal tissues. The methodology includes testing this inhibitor in preclinical models to assess its effectiveness and safety.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that have homozygous deletions of the ENO1 gene, such as certain glioblastomas.
Not a fit: Patients whose cancers do not exhibit the specific genetic deletions targeted by this research may not receive any benefit.
Why it matters
Potential benefit: If successful, this research could provide a targeted treatment option for patients with specific types of cancer that exhibit certain genetic deletions.
How similar studies have performed: This approach is innovative and has shown promising results in preclinical models, indicating potential for success in treating specific cancer types.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Millward, Steven W — University of Tx Md Anderson Can Ctr
- Study coordinator: Millward, Steven W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.