Targeting cancer-causing proteins in fusion-driven sarcoma
Targeting transcriptional addiction in fusion-driven sarcoma
This study is working on new medicines that can specifically target and block certain proteins that help some cancers, like sarcomas, grow, with the goal of finding better treatments to slow down or stop the cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10987878 on NIH RePORTER |
What this research studies
This research focuses on developing new small molecule drugs that can specifically target and disrupt the function of fusion proteins responsible for driving certain types of cancer, particularly sarcomas. By understanding how these proteins manipulate the transcriptional machinery in cells, the research aims to create therapies that can effectively impair their oncogenic activity. The approach involves advanced techniques like CRISPR screening to identify potential drug targets and assess their effectiveness in halting cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents and young adults diagnosed with fusion-driven sarcomas.
Not a fit: Patients with sarcomas not driven by fusion proteins or those with other unrelated cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for patients with fusion-driven sarcomas, potentially improving survival rates and quality of life.
How similar studies have performed: While targeting transcriptional fusion proteins is a challenging area, there have been promising advancements in similar approaches, indicating potential for success.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Mcfadden, David Glenn — Ut Southwestern Medical Center
- Study coordinator: Mcfadden, David Glenn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.