Targeting brain tumors with specialized cell therapies
Cell surface receptor targeted therapies for brain tumors
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11047965
This study is exploring a new way to treat aggressive brain tumors called glioblastomas by using specially designed stem cells that can deliver targeted therapies right to the tumor, helping the body's immune system fight back more effectively.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11047965 on ClinicalTrials.gov |
What this research studies
This research focuses on developing new therapies for aggressive brain tumors, specifically glioblastomas, which are often resistant to standard treatments. The approach involves using engineered mesenchymal stem cells that can deliver targeted therapies directly to the tumor site. These stem cells are designed to release bi-specific T cell engagers that activate the body's immune response against the tumor. By utilizing mouse models, the research aims to demonstrate the effectiveness of this innovative treatment strategy in reducing tumor growth.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who have not responded well to standard therapies.
Not a fit: Patients with non-brain tumors or those who have already exhausted all treatment options may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel and effective treatment option for patients with glioblastomas, potentially improving survival rates and quality of life.
How similar studies have performed: Previous studies have shown promising results with engineered T cell therapies in hematological cancers, but this approach for solid tumors like glioblastomas is still being explored.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAH, KHALID A — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: SHAH, KHALID A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.