Targeting brain-selective estrogen therapy to alleviate menopausal hot flushes
Brain-selective estrogen therapy for menopausal hot flushes in an advanced translational animal model
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11041063
This study is looking at a new way to help women who are dealing with severe hot flushes during menopause by using a special type of estrogen that targets the brain, aiming to make their lives better without the usual side effects of traditional treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11041063 on ClinicalTrials.gov |
What this research studies
This research investigates a new approach to alleviate menopausal hot flushes by focusing on brain-selective estrogen therapy. It aims to improve the quality of life for women experiencing severe menopausal symptoms, particularly hot flushes, which can also affect mood and cognitive function. The study utilizes advanced translational animal models to explore the efficacy and safety of this therapy, minimizing unwanted side effects associated with traditional estrogen treatments. By understanding how estrogen affects the brain, the research seeks to develop safer and more effective treatments for menopausal symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women experiencing severe hot flushes and related menopausal symptoms.
Not a fit: Patients who are premenopausal or those who do not experience menopausal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for menopausal women suffering from hot flushes and related symptoms.
How similar studies have performed: While there have been studies on estrogen therapy, this approach focusing on brain-selective treatment is novel and has not been extensively tested.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MERCHENTHALER, ISTVAN JOZSEF — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: MERCHENTHALER, ISTVAN JOZSEF
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome