Targeting brain inflammation in aging and Alzheimer's disease
A novel approach for targeting neuroinflammation in brain aging and Alzheimer's disease
This research is exploring a new way to reduce brain inflammation, which may help protect against memory decline in aging and Alzheimer's disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-11199650 on NIH RePORTER |
What this research studies
We know that aging increases the risk for Alzheimer's disease, and brain inflammation plays a role in this process. This project is testing a new type of medicine called Nanoligomers, which are designed to specifically target and reduce key inflammatory signals in the brain. Our early work in laboratory models suggests these Nanoligomers could improve memory and reduce inflammation. We will conduct detailed studies to see if these Nanoligomers can protect brain function in models of aging and Alzheimer's disease.
Who could benefit from this research
Good fit: This preclinical work is foundational for future treatments that could benefit individuals at risk for or in the early stages of Alzheimer's disease, or those experiencing age-related cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia may not directly benefit from this specific therapeutic approach, as it focuses on early intervention and prevention.
Why it matters
Potential benefit: If successful, this work could lead to a new treatment that slows down brain aging and prevents or reduces the progression of Alzheimer's disease.
How similar studies have performed: Pilot studies using these novel Nanoligomers have shown promising results in reducing neuroinflammation and enhancing memory in animal models, suggesting a strong foundation for this new direction.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Larocca, Thomas — Colorado State University
- Study coordinator: Larocca, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.