Targeting brain immune cells for new treatments
Unlocking microglia targeting for neurotherapeutics
['FUNDING_OTHER'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10932153
This study is exploring ways to change brain immune cells called microglia to help them better fight infections, which could lead to new treatments for kids with certain brain-related health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10932153 on ClinicalTrials.gov |
What this research studies
This research focuses on microglia, the immune cells in the brain that play a crucial role in responding to injury and infection. The project aims to develop methods to genetically engineer these cells using advanced techniques like CRISPR and lentiviruses, which could lead to new therapies for neurological diseases. By understanding how microglia can be manipulated, the research seeks to enhance their ability to fight viral infections and improve patient outcomes. The work is particularly relevant for children with neuroimmunological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with neuroimmunological conditions, such as leukodystrophies and interferonopathies.
Not a fit: Patients with neurological conditions unrelated to immune responses or those who do not have access to the required genetic therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for neurological diseases by harnessing the power of microglia.
How similar studies have performed: Other research has shown promise in manipulating immune cells for therapeutic purposes, but this specific approach using microglia and CRISPR is relatively novel.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BENNETT, MARIKO L. — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: BENNETT, MARIKO L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus