Targeting brain cell changes in Alzheimer's disease and related dementias
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related Dementias
This study is looking at how certain brain cells called reactive astrocytes might affect Alzheimer's disease and similar conditions, using mouse models to see how changes in these cells could lead to new treatments that help people with dementia.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11116109 on NIH RePORTER |
What this research studies
This research investigates the role of reactive astrocytes, a type of brain cell, in Alzheimer's disease and related dementias. The team will use advanced techniques to modify these cells and study their effects in mouse models that mimic human conditions. They aim to understand how these changes impact brain function and validate their findings using data from both deceased and living individuals. The ultimate goal is to uncover new therapeutic strategies that could improve outcomes for patients with dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other types of cognitive impairment not related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or even reverse the effects of Alzheimer's disease and related dementias.
How similar studies have performed: Other research has shown promise in targeting astrocyte functions, suggesting that this approach could lead to significant advancements in dementia treatment.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Norris, Christopher Mark — University of Kentucky
- Study coordinator: Norris, Christopher Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.