Targeting bone changes to fight breast cancer spread
Modulation of Epigenetic Target in the Bone to Treat Breast Cancer Metastasis
This study is looking at how changes in the bones can affect the way breast cancer spreads to other parts of the body, with the goal of finding new ways to stop this from happening and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11063576 on NIH RePORTER |
What this research studies
This research investigates how changes in the bone environment can influence the spread of breast cancer to other organs. It focuses on understanding the mechanisms behind bone metastasis and how cancer cells can become more aggressive after settling in the bone. By studying these processes, the research aims to identify new strategies to prevent the spread of cancer from the bone to other vital organs, potentially improving patient outcomes. The approach includes advanced genomic analyses and pre-clinical models to explore the relationship between bone lesions and subsequent metastases.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with breast cancer who have experienced metastasis to the bone.
Not a fit: Patients whose breast cancer has not metastasized to the bone may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the spread of breast cancer from the bone to other organs, improving survival rates.
How similar studies have performed: While there has been significant research on primary tumor metastasis, this specific focus on metastasis-to-metastasis seeding from bone lesions is relatively novel and underexplored.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Zhang, Xiang — Baylor College of Medicine
- Study coordinator: Zhang, Xiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.