Targeting bone cancer to prevent breast cancer spread
Official title: Modulation of Epigenetic Target in the Bone to Treat Breast Cancer Metastasis
Funded at Rice University · NIH-10880591 · Data updated 2026-11-12
This study is looking at new ways to stop breast cancer from spreading to the bones after treatment, using special therapies that target bone tissue, and it's designed for anyone affected by breast cancer who wants to learn about potential new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 3, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $619,441 |
| NIH project number | 5R01CA277838-02 |
| Project ID | NIH-10880591 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are breast cancer survivors who are at risk of developing bone metastases.
✕Less likely to help
Patients who do not have a history of breast cancer or those whose cancer has not spread to the bones may not benefit from this research.
What this research studies
This research investigates how to prevent breast cancer from spreading to the bones, which is a common occurrence after initial treatment. It focuses on developing new therapies that use epigenetic inhibitors, which are modified to specifically target bone tissue. By understanding the biology of bone metastases, the researchers aim to create effective treatments that can stop cancer cells from surviving and spreading from the bones to other organs. The study involves collaboration between Rice University and Baylor College of Medicine to enhance the effectiveness of these therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of breast cancer metastasizing to the bones and other organs.
How similar studies have gone: Previous research has shown promise in using targeted therapies for cancer treatment, but this specific approach is novel and aims to address a significant gap in breast cancer care.
Where this research is happening
-
Rice University
Houston, United States Active
Researchers
- Principal investigator: Xiao, Han — Rice University
- Study coordinator: Xiao, Han
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.