Targeting BET proteins in solitary fibrous tumor (SFT)
Bromodomain and extra-terminal motif (BET) inhibitors in Solitary fibrous tumor (SFT)
Testing whether drugs that block BET proteins can slow growth or shrink solitary fibrous tumors in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-11306032 on NIH RePORTER |
What this research studies
You would be learning about a rare soft-tissue cancer called solitary fibrous tumor that often comes back after surgery and has no standard chemotherapy. Researchers are testing drugs called BET inhibitors that block proteins which help cancer cells turn on growth programs. They will use laboratory models and gene-editing tools like CRISPR to find which tumor types depend on BET proteins and why. The results are intended to guide new treatments and future clinical trials for people with SFT.
Who could benefit from this research
Good fit: Adults diagnosed with solitary fibrous tumor, especially those with recurrent, metastatic, or unresectable disease, would be the most relevant candidates for follow-up trials.
Not a fit: People with cancers other than SFT or whose tumors lack the specific molecular features targeted by BET inhibitors may not benefit from this approach.
Why it matters
Potential benefit: If successful, this work could lead to new drug options that shrink tumors or slow disease progression for people with SFT.
How similar studies have performed: BET inhibitors have shown activity in some laboratory and early clinical cancer studies but have not yet demonstrated clear, consistent success for SFT specifically.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: Bleris, Leonidas — University of Texas Dallas
- Study coordinator: Bleris, Leonidas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.