Targeting B7-H3 to reduce tumor growth in a type of childhood brain cancer
Official title: Silencing B7-H3 mitigates tumor aggressiveness in group 3 medulloblastoma
Funded at University of Nebraska Medical Center · NIH-11042380 · Data updated 2026-11-12
This study is looking at a type of brain cancer in kids called medulloblastoma, especially the group 3 kind that is tough to treat, and it’s testing a new way to block a protein that helps the cancer grow, hoping to find better treatments to help kids with this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $76,750 |
| NIH project number | 1R03CA297351-01 |
| Project ID | NIH-11042380 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old diagnosed with group 3 medulloblastoma.
✕Less likely to help
Patients with other types of medulloblastoma or those over 11 years old may not benefit from this research.
What this research studies
This research focuses on medulloblastoma, a common and aggressive brain cancer in children, particularly the group 3 subtype which has a low survival rate. The study aims to silence a protein called B7-H3 that is linked to cancer cell growth and metastasis. By using a specific compound, B7-H3-Ni1, researchers hope to inhibit the growth and invasiveness of these cancer cells. The approach involves screening various molecules to find effective treatments that can potentially improve outcomes for affected children.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that significantly improve survival rates for children with aggressive medulloblastoma.
How similar studies have gone: Previous research has shown promise in targeting similar pathways in other aggressive cancers, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Mahapatra, Sidharth — University of Nebraska Medical Center
- Study coordinator: Mahapatra, Sidharth
Related research
Other NIH-funded projects on the same topics.
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Overcoming medulloblastoma resistance in kids using in vivo perturb-seq and preclinical therapies
A patient-focused study aiming to find new, less toxic ways to treat pediatric medulloblastoma by using advanced genetic screening to identify effective drug targets in preclinical models.
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Dysregulation of a key gene complex and its role in Group 4 medulloblastoma
A study explores how disruption of a core gene complex in brain development may drive Group 4 medulloblastoma and seeks to understand new ways to help affected children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.