Targeting arthritis treatment using special peptides in a mouse model
Official title: Validation of the joint-homing and drug delivery attributes of novel peptides in a mouse arthritis model
Funded at Baltimore VA Medical Center · NIH-11229564 · Data updated 2026-11-12
This study is exploring a new way to help people with rheumatoid arthritis by using a special delivery system to send a powerful anti-inflammatory medicine right to the joints that hurt, aiming to make treatment more effective and reduce side effects, especially for U.S. Veterans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baltimore VA Medical Center NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I21BX005665-03 |
| Project ID | NIH-11229564 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from rheumatoid arthritis, especially those who are U.S. Veterans.
✕Less likely to help
Patients with forms of arthritis other than rheumatoid arthritis may not benefit from this research.
What this research studies
This research investigates a new method for treating rheumatoid arthritis (RA) by using a peptide-guided drug delivery system. The approach involves using a specific peptide to direct liposomes containing the anti-inflammatory drug dexamethasone directly to the joints affected by arthritis in a rat model. This targeted delivery aims to enhance the effectiveness of the treatment while minimizing side effects. The study focuses on improving the quality of life for individuals suffering from RA, particularly among U.S. Veterans.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for rheumatoid arthritis.
How similar studies have gone: Previous research has shown promising results with targeted drug delivery systems in similar contexts, indicating potential for success in this approach.
Where this research is happening
-
Baltimore VA Medical Center
Baltimore, United States Active
Researchers
- Principal investigator: Moudgil, Kamal D — Baltimore VA Medical Center
- Study coordinator: Moudgil, Kamal D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.