Targeting and editing specific cell types using RNA technology
RNA-programmable cell-type targeting, editing, and therapy
This study is working on a new way to target and control specific types of cells using a special technology, which could help us better understand how cells work in health and disease, making it easier to develop better treatments for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10885216 on NIH RePORTER |
What this research studies
This research focuses on developing a new technology that allows for the precise targeting and manipulation of specific cell types using RNA programming. By leveraging advancements in single-cell transcriptome profiling, the project aims to create a method that is efficient, cost-effective, and applicable across various organs and species. This approach seeks to overcome current limitations in cell-type manipulation, which often rely on slow and ethically challenging methods. The goal is to enhance our understanding of cell functions in health and disease, ultimately leading to improved therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve specific cell type dysfunction or abnormalities.
Not a fit: Patients with conditions unrelated to cell type manipulation or those who do not have identifiable cell type issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking therapies that precisely target and edit specific cell types, improving treatment outcomes for various diseases.
How similar studies have performed: Other research has shown success with CRISPR-based approaches for gene manipulation, indicating potential for similar advancements in cell-type targeting.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Huang, Z Josh — Duke University
- Study coordinator: Huang, Z Josh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.