Targeting an enzyme to improve memory in older adults
Official title: Pharmacologic Inhibition of PDE11A for Age-Related Memory Disorders
Funded at Montclair State University · NIH-10830927 · Data updated 2026-11-12
This study is looking at how a specific enzyme, PDE11A, affects memory loss as we get older, using mice to learn more about it, with the hope of finding new treatments to help older adults who are having trouble with their memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montclair State University NIH-funded |
| Lab location | 1 site (Montclair, United States) |
| Project start | September 15, 2020 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $678,484 |
| NIH project number | 5R01AG067836-05 |
| Project ID | NIH-10830927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing memory decline or related cognitive issues.
✕Less likely to help
Patients with memory disorders not related to aging or those with other neurological conditions may not benefit from this research.
What this research studies
This research investigates the role of an enzyme called phosphodiesterase 11A (PDE11A) in age-related memory loss. By studying mice that lack this enzyme, researchers aim to understand how PDE11A contributes to memory decline as people age. The project involves developing selective inhibitors for PDE11A, which could potentially restore memory function. The findings could lead to new treatments for elderly individuals experiencing memory disorders.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for age-related memory disorders, improving the quality of life for older adults.
How similar studies have gone: While PDE11A has not been extensively studied in humans, other PDE inhibitors have shown promise in treating various neurodegenerative conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
Montclair State University
Montclair, United States Active
Researchers
- Principal investigator: Rotella, David — Montclair State University
- Study coordinator: Rotella, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.