Targeting aggressive lymphomas in HIV-positive individuals caused by Epstein-Barr virus
Synthetic lethal targeting of EBV-positive diffuse large B cell lymphomas in persons living with HIV
This study is looking at how the Epstein-Barr virus affects the growth of a type of cancer called diffuse large B-cell lymphoma in people with HIV, and it hopes to find new ways to treat this cancer while keeping healthy cells safe.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10901941 on NIH RePORTER |
What this research studies
This research investigates how the Epstein-Barr virus (EBV) contributes to the development of diffuse large B-cell lymphoma (DLBCL) in individuals living with HIV. The study focuses on understanding the mechanisms by which EBV alters DNA repair processes in cancer cells, particularly how it activates the STAT3 pathway to promote cell growth while compromising effective DNA repair. By identifying these vulnerabilities, the research aims to develop new therapeutic strategies that specifically target these cancer cells without harming healthy cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have been diagnosed with diffuse large B-cell lymphoma and are positive for the Epstein-Barr virus.
Not a fit: Patients who do not have HIV or those with other types of lymphomas not associated with EBV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for aggressive lymphomas in HIV-positive patients, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in cancer treatment, indicating that this approach may lead to significant advancements in therapy.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Bhaduri-Mcintosh, Sumita — University of Florida
- Study coordinator: Bhaduri-Mcintosh, Sumita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.