Targeting a specific vulnerability in glioblastoma cancer cells
Targeting Cysteine Susceptibility in Glioblastoma
This study is looking at a special way to help people with glioblastoma, a tough type of brain cancer, by using a substance called cysteine to make treatments work better and protect healthy cells, with the hope of improving survival rates for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11080705 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a highly aggressive form of brain cancer, and aims to explore a unique metabolic vulnerability related to cysteine in cancer cells. The approach involves using pre-clinical models to investigate how cysteine influences glucose dependence and oxidative stress in glioma cells. By combining cysteine-promoting compounds with existing treatments, the research seeks to enhance the effectiveness of therapies while minimizing damage to healthy tissues. The ultimate goal is to improve survival rates for patients with glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking new treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for glioblastoma patients, potentially improving survival rates and quality of life.
How similar studies have performed: While the specific approach of targeting cysteine in glioblastoma is novel, similar strategies targeting metabolic vulnerabilities in cancer have shown promise in other studies.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Noch, Evan K. — Ut Southwestern Medical Center
- Study coordinator: Noch, Evan K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.