Targeting a specific site on the mu opioid receptor to improve pain relief without addiction.
Official title: Efficacy and signaling modulation by targeting the sodium site at mu opioid receptor
Funded at Washington University · NIH-11128510 · Data updated 2026-11-12
This study is looking for new ways to help people manage pain more safely by finding better options that work with the body's natural pain relief system, so patients can get relief without the usual risks of addiction or breathing problems that come with traditional opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $583,724 |
| NIH project number | 5R01DA059978-02 |
| Project ID | NIH-11128510 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from moderate to severe chronic pain who are at risk of opioid dependence.
✕Less likely to help
Patients who do not experience chronic pain or those who are not responsive to opioid treatments may not benefit from this research.
What this research studies
This research investigates how to enhance pain relief by targeting the sodium site on the mu opioid receptor, which is involved in the body's response to opioids. The study aims to identify new compounds that can activate specific signaling pathways to provide effective analgesia while minimizing side effects like respiratory depression and addiction. By using advanced techniques such as cryo-electron microscopy, researchers will explore how different compounds interact with the receptor and their potential to offer safer pain management options. Patients may benefit from new treatments that provide pain relief without the risks associated with traditional opioids.
Why it matters
Potential benefit: If successful, this research could lead to safer pain management options that reduce the risk of addiction and other serious side effects.
How similar studies have gone: Previous research has shown promise in targeting specific pathways in opioid receptors, suggesting potential for success in this novel approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Majumdar, Susruta — Washington University
- Study coordinator: Majumdar, Susruta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.