Targeting a specific RNA to treat blood vessel dysfunction
Official title: Development of lesion-targeted lncRNA nanotherapeutic for vascular smooth muscle dysfunction
Funded at Arizona State University-Tempe Campus · NIH-11192960 · Data updated 2026-11-12
This study is looking at a way to help people who have thickening of their blood vessels after procedures like angioplasty or stenting, by using a special treatment that delivers a helpful molecule to the affected areas to keep their blood flow healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | September 24, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $407,975 |
| NIH project number | 1R56HL173828-01 |
| Project ID | NIH-11192960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced vascular interventions and are at risk for neointimal hyperplasia.
✕Less likely to help
Patients who do not have a history of vascular interventions or those with conditions unrelated to vascular smooth muscle dysfunction may not benefit from this research.
What this research studies
This research focuses on addressing neointimal hyperplasia, a condition that leads to thickening of arterial walls and reduced blood flow after vascular interventions. It investigates the role of a long noncoding RNA, CARMN, which is crucial for the proper function of vascular smooth muscle cells. By developing a targeted nanotherapeutic that delivers CARMN transcripts directly to affected areas, the research aims to restore normal cell function and prevent complications associated with vascular damage. Patients may benefit from improved outcomes in procedures like angioplasty and stenting.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and outcomes for patients undergoing vascular interventions.
How similar studies have gone: Previous studies have shown promising results with similar approaches targeting RNA for vascular conditions, indicating potential for success in this novel application.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Wang, Mark Kuei-Chun — Arizona State University-Tempe Campus
- Study coordinator: Wang, Mark Kuei-Chun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.