Targeting a specific receptor to improve treatment for inflammatory neuropathies
Official title: Modulation of CSF1R Signaling to Treat Inflammatory Neuropathies
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10997374 · Data updated 2026-11-12
This study is looking at how a specific treatment might help people with Guillain-Barré syndrome by blocking a receptor that contributes to nerve damage, with the hope of finding better options for those who are struggling with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $512,221 |
| NIH project number | 5R01NS134989-02 |
| Project ID | NIH-10997374 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Guillain-Barré syndrome, particularly those who have not responded well to existing treatments.
✕Less likely to help
Patients with chronic neuropathies or those whose conditions are not related to inflammatory processes may not benefit from this research.
What this research studies
This research investigates the role of the colony stimulating factor 1 receptor (CSF1R) in the treatment of Guillain-Barré syndrome (GBS), a condition that can cause acute flaccid paralysis. The study aims to explore how blocking this receptor can reduce nerve injury caused by inflammatory cells during the acute phase of GBS. By focusing on the mechanisms that lead to nerve damage, the research seeks to develop more effective immunomodulatory treatments that could benefit patients who currently have limited options. The approach includes both human studies and animal models to validate the findings.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from inflammatory neuropathies, potentially reducing long-term disability.
How similar studies have gone: Previous research has shown promise in targeting similar inflammatory pathways, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Sheikh, Kazim a — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Sheikh, Kazim a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.