Targeting a specific receptor to improve breast cancer treatment
Official title: SR-A as a therapeutic target in breast cancer
Funded at Univ of Arkansas for Med Scis · NIH-11002682 · Data updated 2026-11-12
This study is looking at how a specific receptor called SR-A affects immune cells in breast cancer, with the goal of finding ways to help these cells better fight tumors.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $178,819 |
| NIH project number | 5R21CA280448-02 |
| Project ID | NIH-11002682 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with aggressive breast cancer who may benefit from novel immunotherapeutic approaches.
✕Less likely to help
Patients with non-aggressive forms of breast cancer or those who do not express the SR-A receptor may not receive benefit from this research.
What this research studies
This research investigates how a receptor called SR-A influences the behavior of immune cells known as macrophages in breast cancer. By understanding how SR-A promotes a tumor-supportive environment, the researchers aim to develop strategies to inhibit its function. This could potentially repolarize macrophages to fight against tumors more effectively. The study uses animal models to analyze gene expression and the effects of SR-A on tumor progression and metastasis.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response against breast cancer, potentially improving patient outcomes.
How similar studies have gone: Other research has shown promising results in targeting immune cell behavior in cancer, suggesting that this approach could be a viable strategy.
Where this research is happening
-
Univ of Arkansas for Med Scis
Little Rock, United States Active
Researchers
- Principal investigator: Post, Steven — Univ of Arkansas for Med Scis
- Study coordinator: Post, Steven
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.