Targeting a specific protein to treat brain cancer in children
Official title: Targeting histone deacetylase SIRT1 in medulloblastoma
Funded at George Washington University · NIH-11070479 · Data updated 2026-11-12
This study is looking at a protein called SIRT1 to see how it affects the growth of medulloblastoma, a brain cancer that mostly impacts kids, with the hope of finding new ways to slow down or stop the cancer's growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | December 12, 2024 |
| Project end | December 1, 2029 |
| Funding year | 2025 |
| Award (this year) | $477,576 |
| NIH project number | 1R01CA290697-01A1 |
| Project ID | NIH-11070479 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old diagnosed with medulloblastoma.
✕Less likely to help
Patients with other types of brain tumors or those over 11 years old may not benefit from this research.
What this research studies
This research investigates the role of a protein called SIRT1 in the development of medulloblastoma, a type of brain cancer that primarily affects children. The researchers aim to understand how SIRT1 influences cancer progression by regulating cellular processes related to cell growth and function. They will explore the potential of targeting SIRT1 to inhibit the growth of cancer cells in laboratory settings, which could lead to new treatment strategies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for medulloblastoma, improving survival rates and quality of life for young patients.
How similar studies have gone: Previous research has shown promise in targeting similar proteins for cancer treatment, indicating a potential for success in this approach.
Where this research is happening
-
George Washington University
Washington, United States Active
Researchers
- Principal investigator: Seto, Edward — George Washington University
- Study coordinator: Seto, Edward
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Overcoming medulloblastoma resistance in kids using in vivo perturb-seq and preclinical therapies
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.