Targeting a specific protein to slow down tumor growth in oral cancer
Targeted inhibition of eIF5Ahpu suppresses tumor growth and M2-like TAM polarization in oral cancer
This study is looking at a protein called eIF5Ahpu to see if blocking it can help slow down the growth of oral squamous cell carcinoma (a type of head and neck cancer) and change how immune cells act around the tumor, with the hope of finding better treatment options for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11039836 on NIH RePORTER |
What this research studies
This research focuses on oral squamous cell carcinoma (OSCC), a common type of head and neck cancer. It investigates how inhibiting a specific protein, eIF5Ahpu, can suppress tumor growth and alter the behavior of immune cells in the tumor environment. The approach involves analyzing the role of this protein in cancer cell proliferation and immune response, with the goal of developing new therapeutic strategies. Patients may benefit from insights that could lead to improved treatment options for OSCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with oral squamous cell carcinoma.
Not a fit: Patients with other types of cancers or those without a diagnosis of oral cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates for patients with oral cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Le, Anh D — University of Pennsylvania
- Study coordinator: Le, Anh D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.