Targeting a specific protein to improve treatment for neuroblastoma in children
Mechanisms and small-molecule targeting of SWI/SNF activity in neuroblastoma
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10862818
This study is looking at how a protein called SMARCA4 affects neuroblastoma, a serious cancer in kids, to find new ways to treat it that could help children live longer and feel better during treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10862818 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the SMARCA4 protein in neuroblastoma, a common and aggressive cancer in young children. By using advanced techniques to inhibit this protein, the researchers aim to understand how it affects cell growth and death in neuroblastoma cells. The study will explore the mechanisms behind cell cycle regulation and how targeting this protein can lead to better treatment outcomes. Patients may benefit from new therapeutic strategies that could improve survival rates and reduce side effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with high-risk neuroblastoma, particularly those under 11 years old.
Not a fit: Patients with neuroblastoma who are not classified as high-risk or those who are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for neuroblastoma, potentially increasing survival rates and minimizing harmful side effects.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HODGES, HAMILTON COURTNEY — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: HODGES, HAMILTON COURTNEY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.