Targeting a specific protein to improve nerve repair and reduce pain
Official title: Targeting LRP1 in Neuroinflammation and Neuropathic Pain
Funded at VA San Diego Healthcare System · NIH-11015807 · Data updated 2026-11-12
This study is looking at how a special protein called LRP1 can help nerve-supporting cells called Schwann cells heal damaged nerves, which could help people with chronic pain from nerve injuries feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX006386-02 |
| Project ID | NIH-11015807 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic neuropathic pain due to peripheral nerve injuries.
✕Less likely to help
Patients with pain not related to peripheral nerve injuries or those with conditions that do not involve Schwann cell activation may not benefit from this research.
What this research studies
This research investigates how Schwann cells, which support nerve function, can be activated to repair peripheral nerve injuries. The study focuses on a protein called LRP1 that plays a crucial role in the repair process. By understanding how this protein interacts with other molecules, the researchers aim to enhance the healing of nerves and alleviate chronic pain, particularly in individuals who have experienced nerve damage. The approach involves advanced techniques to analyze protein interactions and their effects on nerve cell behavior.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic neuropathic pain that do not involve addictive medications.
How similar studies have gone: Previous research has shown promise in targeting similar pathways for nerve repair, suggesting that this approach could be effective.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Campana, Wendy M. — VA San Diego Healthcare System
- Study coordinator: Campana, Wendy M.
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.