Targeting a specific protein to help control epileptic seizures
Targeting TRPC3 Channels for Epileptic Seizures
['FUNDING_OTHER'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-10809528
This study is looking at a protein called TRPC3 to see if blocking it can help reduce the number and intensity of seizures in people with epilepsy who don’t respond well to current medications, with the hope of finding new treatments that can make a real difference.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10809528 on ClinicalTrials.gov |
What this research studies
This research focuses on a protein called TRPC3, which is involved in the regulation of calcium influx in brain cells. The study aims to explore how inhibiting TRPC3 can potentially reduce the frequency and severity of epileptic seizures, particularly in patients who do not respond well to existing anti-seizure medications. By investigating the role of TRPC3 in the brain's signaling pathways, the researchers hope to develop new therapies that not only alleviate seizures but also prevent the progression of epilepsy. The approach includes both laboratory experiments and potential future clinical applications for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with epilepsy who have not found relief from current anti-seizure medications.
Not a fit: Patients with epilepsy who respond well to existing treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for epilepsy, improving the quality of life for many patients.
How similar studies have performed: Other research has shown promise in targeting similar pathways for seizure control, suggesting that this approach could be a viable new strategy.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIANG, JIANXIONG — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: JIANG, JIANXIONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.