Targeting a specific protein in enteroviruses to develop new treatments
Enteroviral 2C protein as a therapeutic target
This study is looking at a specific protein in non-polio enteroviruses that can make kids sick, and by figuring out how to block this protein, the researchers hope to create new treatments to help protect infants and children from these viruses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11055352 on NIH RePORTER |
What this research studies
This research focuses on non-polio human enteroviruses, which pose a significant health risk to infants and children. The study aims to investigate a specific protein called 2C, which is crucial for the virus's replication and assembly. By understanding how this protein functions and how it can be inhibited, the researchers hope to develop treatments that can work against multiple strains of these viruses. The approach involves biochemical and biophysical methods to explore the mechanisms of action of existing inhibitors and to guide the design of new therapeutic agents.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and children under 11 years old who are at risk for enteroviral infections.
Not a fit: Patients who are adults or those without a history of enteroviral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for enteroviral infections in children.
How similar studies have performed: Previous research has shown promise in targeting similar viral proteins, indicating potential for success in this approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Cameron, Craig E. — Univ of North Carolina Chapel Hill
- Study coordinator: Cameron, Craig E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.