Targeting a specific part of the energy production process in a type of leukemia
Targeting mitochondrial complex I in acute lymphoblastic leukemia
This study is looking at a new drug called IACS-010759 that might help adults with T-cell acute lymphoblastic leukemia (T-ALL) by blocking the energy that cancer cells need to grow, and it aims to see if combining this drug with regular chemotherapy can lead to better results for those whose cancer has come back.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10918130 on NIH RePORTER |
What this research studies
This research focuses on T-cell acute lymphoblastic leukemia (T-ALL), a severe blood cancer that often relapses in adults despite treatment. The study investigates how targeting mitochondrial Complex I, a key component in energy production, can inhibit the growth of T-ALL cells. Researchers have identified a promising drug, IACS-010759, which has shown effectiveness in laboratory settings by blocking energy production in cancer cells while sparing normal cells. The goal is to combine this drug with existing chemotherapy treatments to improve outcomes for patients with relapsed T-ALL.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with relapsed T-cell acute lymphoblastic leukemia.
Not a fit: Patients with other types of leukemia or those who are not relapsed may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for adults with T-ALL, potentially improving survival rates.
How similar studies have performed: Previous research has shown promising results in targeting oxidative phosphorylation in cancer cells, suggesting that this approach may be effective.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Konopleva, Marina Y — Albert Einstein College of Medicine
- Study coordinator: Konopleva, Marina Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.