Targeting a specific metabolic pathway in cancer cells
Therapeutic Targeting Mitochondrial C1 Metabolism
This study is looking at how cancer cells change the way they use energy to grow and survive, and it’s testing new treatments that could help slow down or stop this process, which might be helpful for people with different types of cancer like ovarian, lung, colorectal, and pancreatic cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11003690 on NIH RePORTER |
What this research studies
This research investigates how cancer cells alter their metabolism, specifically focusing on a pathway known as one-carbon (C1) metabolism that is crucial for their growth and survival. The study explores novel compounds that inhibit this pathway, potentially leading to reduced cancer cell proliferation. By targeting a specific enzyme involved in this process, the research aims to develop new anti-cancer therapies that could be effective against various types of cancer, including ovarian, lung, colorectal, and pancreatic cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with epithelial ovarian cancer, non-small cell lung cancer, colorectal cancer, or pancreatic cancer.
Not a fit: Patients with cancers not targeted by this research or those who do not have a metabolic profile amenable to the intervention may not benefit.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively slow down or stop the growth of certain cancers.
How similar studies have performed: Other research has shown promise in targeting metabolic pathways in cancer, suggesting that this approach could be a viable strategy for developing new therapies.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Matherly, Larry H — Wayne State University
- Study coordinator: Matherly, Larry H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.