Targeting a specific immune pathway to improve cancer treatment
Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapy
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11083106
This study is looking at how a substance called Tryptophan affects the immune system in people with solid tumors, and it aims to find better ways to use immunotherapy alongside other treatments to help the body fight cancer more effectively.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11083106 on ClinicalTrials.gov |
What this research studies
This research investigates how the metabolism of Tryptophan affects the immune response in patients with solid tumors. By focusing on the Kynurenine-aryl hydrocarbon receptor (AHR) pathway, the study aims to understand how this pathway suppresses immune cells that fight tumors. The researchers will use imaging techniques to monitor the activity of this pathway and optimize the timing of combined drug treatments with immunotherapy. This approach could help overcome resistance to current cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors who have not responded to existing immunotherapies or have developed resistance.
Not a fit: Patients with non-solid tumors or those who have not undergone immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of immunotherapy for patients with solid tumors.
How similar studies have performed: Other research has shown promising results in targeting similar immune pathways to improve cancer treatment outcomes.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MERGHOUB, TAHA — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: MERGHOUB, TAHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.