Targeting a specific gene to treat aggressive brain tumors
Targeting AVIL in Glioblastoma
This study is looking at a gene called AVIL that seems to help brain tumors called glioblastomas grow, and the researchers want to see if turning off this gene can help shrink the tumors in people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10769739 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma multiforme (GBM), a highly aggressive brain tumor. The team has identified a gene called AVIL that is overexpressed in GBM cells but not in healthy brain cells. By silencing this gene, they have observed significant tumor reduction in laboratory settings and animal models. The research aims to further explore AVIL as a potential therapeutic target and biomarker for treatment sensitivity in patients with GBM.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma multiforme who are seeking new treatment options.
Not a fit: Patients with other types of brain tumors or those who do not have glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that improve survival rates for patients with glioblastoma.
How similar studies have performed: Previous studies have shown promising results in targeting similar oncogenes in other cancers, indicating potential for success in this novel approach.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Li, Hui — University of Virginia
- Study coordinator: Li, Hui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.