Targeting a specific gene to improve treatment for sepsis
Official title: Bach1 as a molecular target in sepsis
Funded at Charlie Norwood VA Medical Center · NIH-10694541 · Data updated 2026-11-12
This study is looking at how a gene called BACH1 affects recovery from sepsis, especially in Veterans, to find new ways to help people heal better after this serious condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Charlie Norwood VA Medical Center NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 1I01BX006256-01 |
| Project ID | NIH-10694541 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been diagnosed with sepsis, especially Veterans who are at higher risk.
✕Less likely to help
Patients who do not have sepsis or related conditions may not receive any benefit from this research.
What this research studies
This research investigates the role of the BACH1 gene in sepsis, a severe condition affecting many individuals, particularly Veterans. By exploring how BACH1 regulates other important genes and its impact on organ function and survival during sepsis, the study aims to develop new treatment strategies. The approach involves using a bioenergetic method to understand how modifying BACH1 can enhance recovery from sepsis. Patients may benefit from potential new therapies that improve outcomes after sepsis.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve survival rates and recovery for patients suffering from sepsis.
How similar studies have gone: Previous research has shown promise in targeting similar molecular pathways for improving outcomes in sepsis, indicating that this approach may be viable.
Where this research is happening
-
Charlie Norwood VA Medical Center
Augusta, United States Active
Researchers
- Principal investigator: Raju, Raghavan Pillai — Charlie Norwood VA Medical Center
- Study coordinator: Raju, Raghavan Pillai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.