Targeting a specific gene in aggressive brain tumors
Therapeutic Targeting in EGFR-amplified Glioblastoma
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11075217
This study is looking at a specific gene related to glioblastomas, a tough type of brain tumor, to see how it helps the tumor grow and how it might lead to new treatments that could help patients with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11075217 on ClinicalTrials.gov |
What this research studies
This research focuses on glioblastomas, which are highly malignant brain tumors with poor outcomes. It aims to investigate a gene called EGFR long non-coding downstream RNA (ELDR), which is often amplified alongside the EGFR gene in these tumors. By understanding how ELDR contributes to tumor growth and interacts with other proteins, the research seeks to develop new therapeutic strategies that could improve treatment outcomes for patients with EGFR-amplified glioblastoma. The approach includes exploring non-canonical pathways that may provide new targets for therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with EGFR-amplified glioblastoma.
Not a fit: Patients with glioblastoma that does not have EGFR amplification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with EGFR-amplified glioblastoma, potentially improving survival rates.
How similar studies have performed: While targeting EGFR has been challenging, this research explores novel pathways and may build on previous successes in targeting other oncogenic drivers in cancer.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHENG, SHI-YUAN — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: CHENG, SHI-YUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.