Targeting a specific enzyme to treat cancer
Targeting the detoxification function of the enzyme KDSR for cancer therapy
This study is looking at how blocking a specific enzyme called KDSR can make cancer cells less healthy by causing a buildup of harmful substances, and it hopes to find out which types of cancer might be most affected, so that new treatments can be developed to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10993196 on NIH RePORTER |
What this research studies
This research investigates the role of the enzyme KDSR in cancer cells, focusing on how its inhibition can lead to the accumulation of toxic metabolites that harm cancer cells. By understanding the metabolic pathways involved, the researchers aim to identify cancer types that are particularly dependent on KDSR for detoxification. The study will explore how disrupting this enzyme can impair the function of cancer cells, potentially leading to new therapeutic strategies. Patients may benefit from targeted therapies that exploit this vulnerability in their cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with specific types of cancer that show elevated levels of the toxic metabolite 3KDS and are dependent on KDSR for detoxification.
Not a fit: Patients with cancers that do not rely on KDSR for detoxification or those with advanced-stage cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new cancer therapies that specifically target and kill cancer cells by disrupting their detoxification processes.
How similar studies have performed: Other research has shown promise in targeting metabolic enzymes for cancer therapy, indicating that this approach could be a viable strategy.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Kim, Dohoon — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Kim, Dohoon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.