Targeting a specific enzyme to develop non-addictive pain relief medications
The lipid hydrolase NAAA as a target for non-addictive analgesic medications
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10918056
This study is exploring a new way to help people manage pain without the risk of addiction by looking at a specific enzyme called NAAA, and it's testing how blocking this enzyme can reduce pain in animals to eventually create safer pain relief medications for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10918056 on ClinicalTrials.gov |
What this research studies
This research investigates the enzyme N-Acylethanolamine Acid Amidase (NAAA) as a potential target for creating new pain relief medications that do not have the risk of addiction. The study involves testing how inhibiting NAAA can reduce pain responses in animal models, specifically looking at its effects on a lipid messenger that helps suppress pain. By understanding the mechanisms behind NAAA's action, the research aims to develop safer analgesics that can effectively manage pain without the side effects associated with traditional opioids.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from acute pain conditions who are seeking effective pain management options.
Not a fit: Patients with chronic pain conditions or those who do not respond to traditional analgesics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of non-addictive pain relief medications that provide effective treatment for acute pain.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting pain pathways, indicating potential for success in this novel investigation.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PIOMELLI, DANIELE — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: PIOMELLI, DANIELE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.