Targeting a specific cancer marker in pancreatic cancer
Official title: Targeting Disease Specific Tn Antigen in Pancreatic Cancer
Funded at University of Nebraska Medical Center · NIH-11047385 · Data updated 2026-11-12
This study is looking for new treatments for pancreatic cancer that can better target the cancer cells, helping to boost the immune system's ability to fight the disease, especially for those whose cancer is more advanced.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | December 20, 2024 |
| Project end | April 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $117,777 |
| NIH project number | 1R01CA288372-01A1 |
| Project ID | NIH-11047385 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who have advanced or metastatic disease.
✕Less likely to help
Patients with early-stage pancreatic cancer or those whose tumors do not express Tn or Sialyl Tn antigens may not benefit from this research.
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a highly lethal form of cancer that often presents at an advanced stage. The study aims to develop new targeted therapies that specifically attack cancer cells expressing unique carbohydrate antigens known as Tn and Sialyl Tn. These antigens are linked to poor prognosis and are not typically found in healthy pancreatic tissue. By using a novel monoclonal antibody designed to target these antigens, the research seeks to enhance the immune response against the cancer and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pancreatic cancer, potentially improving survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown promise in targeting similar cancer-associated antigens, indicating potential for success with this novel approach.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Radhakrishnan, Prakash — University of Nebraska Medical Center
- Study coordinator: Radhakrishnan, Prakash
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.