Targeting a specific calcium channel in sperm for new contraceptive methods
Engineering and targeting the sperm-specific calcium channel CatSper for contraception
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11017045
This study is exploring a new kind of birth control for men that works by blocking a specific channel in sperm, which could help prevent pregnancy without the side effects of traditional methods.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11017045 on ClinicalTrials.gov |
What this research studies
This research aims to develop a new type of contraceptive by targeting the sperm-specific CatSper calcium channel, which is essential for sperm function and male fertility. The approach involves inhibiting this channel to prevent sperm from fertilizing an egg, offering a non-steroidal option for contraception. The researchers have created innovative chimeric channels to study the mechanism of action and develop reversible contraceptives without negative side effects. This could provide a more effective and comprehensive birth control solution for both men and women.
Who could benefit from this research
Good fit: Ideal candidates for this research are men seeking non-steroidal contraceptive options.
Not a fit: Patients who are not male or those who do not seek contraceptive methods may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new, effective contraceptive method that is safe and reversible for both men and women.
How similar studies have performed: While targeting calcium channels for contraception is a novel approach, similar strategies in other areas of reproductive health have shown promise.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHUNG, JEAN-JU LUCIA — YALE UNIVERSITY
- Study coordinator: CHUNG, JEAN-JU LUCIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.