Targeting a protein to reduce kidney damage in chronic kidney disease.
Official title: Controlling renal oxidative stress in CKD via targeting FGF23 bioactivity
Funded at Jackson Laboratory · NIH-10910933 · Data updated 2026-11-12
This study is looking at how a protein called FGF23 might help protect your kidneys from damage caused by stress, which is important for people with chronic kidney disease, and it hopes to find new ways to improve treatments for better health outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $239,040 |
| NIH project number | 5R00DK129705-04 |
| Project ID | NIH-10910933 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic kidney disease who are experiencing oxidative stress-related complications.
✕Less likely to help
Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
What this research studies
This research investigates how controlling the activity of a protein called FGF23 can help manage oxidative stress in the kidneys, which is a significant factor in the progression of chronic kidney disease (CKD). The approach involves identifying new biological pathways that could be targeted to slow down or halt the deterioration of kidney function. By utilizing advanced techniques in molecular biology and bioinformatics, the research aims to translate these findings into potential therapies that could improve patient outcomes. Patients may benefit from new treatment strategies that arise from this work.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow the progression of chronic kidney disease and improve kidney health.
How similar studies have gone: Previous research has shown promise in targeting oxidative stress pathways in kidney disease, suggesting that this approach could be effective.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Agoro, Rafiou — Jackson Laboratory
- Study coordinator: Agoro, Rafiou
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.