Targeting a protein to inhibit androgen receptor activity in advanced prostate cancer
Androgen receptor pathway inhibition through targeting PARP-2 in castration-resistant prostate cancer
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10880422
This study is looking at how blocking a protein called PARP-2 might change the way a key player in prostate cancer, the androgen receptor, works, with the hope of finding new treatments that could help men with advanced prostate cancer feel better and live longer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10880422 on ClinicalTrials.gov |
What this research studies
This research investigates how inhibiting the protein PARP-2 can affect the activity of the androgen receptor, which plays a crucial role in the progression of castration-resistant prostate cancer. By understanding the molecular mechanisms involved, the research aims to develop new therapeutic strategies that could improve treatment outcomes for patients with advanced prostate cancer. The approach involves studying the interactions between PARP-2 and the androgen receptor to identify potential targets for drug development. Patients may benefit from novel treatments that specifically target these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with castration-resistant prostate cancer who have not responded to standard treatments.
Not a fit: Patients with early-stage prostate cancer or those who are not castration-resistant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively treat advanced prostate cancer.
How similar studies have performed: Other research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIA, LI — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: JIA, LI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.